Benzodiazepine Withdrawal

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Benzodiazepine withdrawal: an unfinished story.

"'I am 39 years old, married, with two children aged 18 years and 14 years. The younger was a very active baby, and when he was 18 months old I mentioned to the doctor that he was sleeping very little and though he did not seem tired in any way, I certainly was! After a course of vitamins I still felt worn out and this was when I was first prescribed Valium. "This was 1971; I was then 27 years ...

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The benzodiazepine withdrawal syndrome and its management.

The literature on benzodiazepine dependence and withdrawal is reviewed with an emphasis on social and psychological considerations. The problems of when to prescribe, identifying withdrawal symptoms, effective communication with the patient, the structure of withdrawal programmes, and the use of drugs, psychological approaches and other services are discussed.

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Predictors of long-term benzodiazepine abstinence in participants of a randomized controlled benzodiazepine withdrawal program.

OBJECTIVE To identify predictors of resumed benzodiazepine use after participation in a benzodiazepine discontinuation trial. METHOD We performed multiple Cox regression analyses to predict the long-term outcome of a 3-condition, randomized, controlled benzodiazepine discontinuation trial in general practice. RESULTS Of 180 patients, we completed follow-up for 170 (94%). Of these, 50 (29%) ...

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Basic pharmacologic mechanisms involved in benzodiazepine tolerance and withdrawal.

Benzodiazepines are widely prescribed for the treatment of anxiety and sleep disorders. Although safe, tolerance develops rapidly to their sedative activity and more slowly to their anticonvulsant activity. In animals anxiolytic tolerance has also been measured. Abrupt cessation of benzodiazepine treatment leads to symptoms of withdrawal. The mechanisms responsible for these phenomena are not k...

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Takotsubo Cardiomyopathy and Catatonia in the Setting of Benzodiazepine Withdrawal

We report two serious and unusual complications of benzodiazepine withdrawal in a single patient: takotsubo cardiomyopathy and catatonia. This 61-year-old female patient was brought to the emergency department with lethargy and within hours had declined into a state of catatonia. Although there was never a complaint of chest pain, ECG showed deep anterior T-wave inversions and cardiac enzymes w...

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ژورنال

عنوان ژورنال: Baylor University Medical Center Proceedings

سال: 1991

ISSN: 0899-8280,1525-3252

DOI: 10.1080/08998280.1991.11929745